RIPK3 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comRIPK3 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > RIPK3(Gene name) > Human

RIPK3 (Gene name),

Receptor-interacting serine/threonine-protein kinase 3 (Protein name ), RIPK3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RIPK3(RIP3);

Protein name:

Receptor-interacting serine/threonine-protein kinase 3;

Alternative:

Receptor-interacting protein 3(RIP-3);RIP-like protein kinase 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Binds TRAF2 is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes.

Function:

Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Subcellular Location:

Cytoplasm Cell membrane Mitochondrion

Protein Attributes:

Sequence length:

518

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

518:

KDPEAWSRPQ | GWYNHSGK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000216274

KEGG:

hsa:11035

MIM:

605817

UniGene:

Hs.268551

Pfam:

PF00069

String:

Q9Y572

SMR:

Q9Y572

Uniprot:

Q9Y572

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

E11168h

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96T

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

E11168m

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96T

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

E11168r

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CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

U11168r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

U11168h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

U11168m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

P11168Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

P11168Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3

Cat.:

P11168Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3

Protein for Human Receptor-interacting serine/threonine-protein kinase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB."
Yu P.W. , Huang B.C.B. , Shen M. , Quast J. , Chan E. , Xu X. , Nolan G.P. , Payan D.G. , Luo Y.
Curr. Biol.9:539-542(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF LYS-50;INTERACTION WITH RIPK1
tissue: Cervix carcinoma.
tissue: Lymphocyte.
2.

"RIP3, a novel apoptosis-inducing kinase."
Sun X. , Lee J. , Navas T. , Baldwin D.T. , Stewart T.A. , Dixit V.M.
J. Biol. Chem.274:16871-16875(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF LYS-50
tissue: Aortic endothelium.
tissue: Fetal brain.
3.

"RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis."
Yang Y. , Hu W. , Feng S. , Ma J. , Wu M.
Biochem. Biophys. Res. Commun.332:181-187(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
4.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Thalamus.
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Blood.
8.

"Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3."
Sun X. , Yin J. , Starovasnik M.A. , Fairbrother W.J. , Dixit V.M.
J. Biol. Chem.277:9505-9511(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RIP HOMOTYPIC INTERACTION MOTIF;PHOSPHORYLATION AT SER-199;INTERACTION WITH RIPK1
9.

"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis."
Zhang D.W. , Shao J. , Lin J. , Zhang N. , Lu B.J. , Lin S.C. , Dong M.Q. , Han J.
Science325:332-336(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PYGL; GLUL AND GLUD1
10.

"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha."
He S. , Wang L. , Miao L. , Wang T. , Du F. , Zhao L. , Wang X.
Cell137:1100-1111(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-199;INTERACTION WITH RIPK1
11.

"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation."
Cho Y.S. , Challa S. , Moquin D. , Genga R. , Ray T.D. , Guildford M. , Chan F.K.
Cell137:1112-1123(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The role of the kinases RIP1 and RIP3 in TNF-induced necrosis."
Vandenabeele P. , Declercq W. , Van Herreweghe F. , Vanden Berghe T.
Sci. Signal.3:RE4-RE4(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
13.

"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."
Bertrand M.J. , Lippens S. , Staes A. , Gilbert B. , Roelandt R. , De Medts J. , Gevaert K. , Declercq W. , Vandenabeele P.
PLoS ONE6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY BIRC2/C-IAP1 AND BIRC3/C-IAP2;INTERACTION WITH BIRC2/C-IAP1; BIRC3/C-IAP2 AND XIAP/BIRC4
14.

"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase."
Sun L. , Wang H. , Wang Z. , He S. , Chen S. , Liao D. , Wang L. , Yan J. , Liu W. , Lei X. , Wang X.
Cell148:213-227(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MLKL;PHOSPHORYLATION AT SER-227;ACTIVE SITE;MUTAGENESIS OF ASP-142 AND SER-227
15.

"The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways."
Wang Z. , Jiang H. , Chen S. , Du F. , Wang X.
Cell148:228-243(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN COMPLEX WITH PGAM5; RIPK1 AND MLKL;MUTAGENESIS OF LYS-50
16.

"Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."
Zhao Y. , Alonso C. , Ballester I. , Song J.H. , Chang S.Y. , Guleng B. , Arihiro S. , Murray P.J. , Xavier R. , Kobayashi K.S. , Reinecker H.C.
Inflamm. Bowel Dis.18:603-612(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF2
17.

"Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis."
Zhao J. , Jitkaew S. , Cai Z. , Choksi S. , Li Q. , Luo J. , Liu Z.G.
Proc. Natl. Acad. Sci. U.S.A.109:5322-5327(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MLKL
18.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-300 AND GLN-492

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